OBJECTIVES: Marfan syndrome is a rare systemic connective tissue disorder caused by mutations in the gene encoding fibrillin-1, which can contribute to serious cardiovascular (CV) and pulmonary related complications. While signs and symptoms may not appear until adulthood, some patients experience disease complications much earlier in life. Therefore, the purpose of this study was to evaluate the burden of CV and pulmonary related manifestations in children diagnosed with Marfan syndrome. METHODS: We used data from the 2012 Kids National Inpatient Sample. Marfan syndrome patients >10 years were identified using ICD-9 code 759.82. Patients were stratified by primary diagnosis; CV (CCS: 096, 097, 100, 101, 103-113, 115-118 or DRG: 025-027, 031-033, 219-221, 229, 230, 307) or pulmonary-related (CCS: 128-131, 133, 134) conditions. The reference group for all analyses included hospital discharges without a primary CV or pulmonary-related diagnosis. Descriptive and inferential statistics were used to compare demographics, healthcare outcomes, and hospital charges. RESULTS: