OBJECTIVES:  The study was designed to evaluate the frequency of administration errors and prevention Strategy in a pediatric ward of a teaching hospital, Quetta, Pakistan. METHODS:  The study was prospective observational based, assessment of all the treatment chart of admitted patients by Pharmacist during the study period and analyzed the medication administration errors as per WHO guidelines. Data was collected from pediatric ward Bolan Medical Complex Hospital, Quetta from the period of October - November 2015 in a data collection form. Data was analyzed by using SPSS version 20. RESULTS:  The total number of 287 patients treatment chart were assessed and the total drug administration were 8179, out of which drug administration to male patients were 5156 (63%) and female patients 3023 (37%). The total administration errors were recorded 6718 (82.13%), which include 6607 (98.34% of total errors) were omission errors, followed by 43 (0.64%) wrong time error, and 41 (0.61%) un-authorized drug error. CONCLUSIONS:  There was a high percentage of administration errors in inpatient settings in which omission error was most frequent administration error made by nurses during the process of medicines administration. The only solution is that the educational training should be provided to nurses improve their administration process skills according to World Health Organization guidelines and Pharmacist intervention is needed in this regard.