OBJECTIVES:  Matching-Adjusted Indirect Comparison (MAIC) in comparative effectiveness research is increasingly used and complements traditional approaches. The NICE Decision Support Unit (DSU) recently published a Technical Support Document (TSD) on population-adjusted indirect comparisons, including recommendations for the application and reporting of MAICs.The objective was to review MAICs in Ankylosing Spondylitis (AS) Psoriatic-Arthritis (PsA) and psoriasis in the context of these recommendations. METHODS: A systematic literature review (2010-2016) and a targeted search in congress proceedings in AS, PsA and psoriasis was conducted to identify published MAICs. We developed a checklist based on the NICE DSU recommendations to assess alignment. This included amongst other criteria if the target population had been clearly stated, evidence of imbalance or heterogeneity between source trials was provided, if all matching variables and effective sample size (ESS) post matching were reported or whether evidence was considered that matched variables included effect modifiers or prognostic variables. RESULTS:  19 MAIC publications were identified: AS (4), PsA (7), psoriasis (8). All were published prior to NICE DSU and included only biologic treatments. Results of the assessment with developed checklist revealed that many publications failed to fully report all items recommended by NICE DSU. Almost all MAICs (n=18) reported baseline variables used for matching. Only 11 reported the ESS and same number of MAICs did not report any measure of uncertainty. A large variability was observed among other criteria such as the rationale for selecting the matching variables, or evidence of imbalance pre matching. CONCLUSIONS: This review of MAICs in AS, PsA and psoriasis showed low compliance to recent NICE DSU TSD recommendations. This research raises important issues to be addressed in each MAIC and can inform future MAIC guidelines.  Phillippo, D.M.,Ades, A.E.,Dias, S.,Palmer,S., Abrams,K.R.,Welton, N.J. NICE DSU Technical Support Document 18:Methods for population-adjusted indirect comparisons in submission to NICE.2016.Available from http://www.nicedsu.org.uk