OBJECTIVES: Health care decisions are made in the context of constrained budgets. Thus, evidence on the health effects of interventions is often not sufficient for decision-making as it also requires evidence on resource use, costs, and their cost-effectiveness. Extending the scope of Cochrane Intervention Reviews (CIRs) to incorporate economic evidence can increase their usefulness in decision-making. We developed a methods framework for conducting a full systematic review of economic evidence which was piloted in a new Cochrane review of interventions for increasing the uptake of Diabetic Retinopathy Screening (DRS). The framework focused on helping end-users help understand key economic trade-offs between alternatives. METHODS: Following the framework, searches were conducted to identify full economic evaluations, cost analyses, or comparative resource utilization studies conducted alongside eligible randomised controlled trials (RCTs). These studies were next classified according to the type of economic evaluation and analytic framework used. Characteristics of included studies and their results were extracted. Risk of bias and overall methodological quality were assessed using the Cochrane Risk of Bias Tool v.1.0 and the CHEERS statement plus CHEC criteria. RESULTS: