OBJECTIVES: Hypogammaglobulinemia (HG) is an immune disorder characterized by a lack in production of gamma globulins. Due to immune deficiencies, patients with HG often have recurrent infections. The purpose of this analysis is to examine hospital resource utilization in patients diagnosed with HG. METHODS: A retrospective analysis was conducted on a cross-section of HG discharges in the MedAssets health system data for October 2015 through September 2016 discharges. Between group differences were tested using Chi-Square for categorical variables and ANOVA for continuous variables. Multivariable logistic regression was used to identify significant drivers of inpatient admission. RESULTS: The sample population included 8670 patients treated in 283 U.S. hospitals. Only 3.1% were diagnosed with hereditary HG (HHG). Not surprisingly the HHG cohort was primarily male (72.1%) however the non-hereditary HG (NHHG) cohort had more females (59.5%). HHG patients were significantly younger (32.7 vs 59.7, p<.0001) and had significantly lower Charlson Comorbidity Index scores (1.1 vs 3.0, p<.0001). The most common comorbidities for HHG included chronic pulmonary disease (CPD, 34.6%), cancer (11.2%), and anemia (10.4%). Cancer (42.5%), CPD (37.5%), other metabolic disorders (29.1%), and anemia (25.5%) were most prevalent in NHHG. Infections were more common in the NHHG cohort (12.2% vs 6.9%, p<.0001). HHG patients had slightly more visits overall (4.0 vs 3.4, p=.0308). Inpatient utilization was higher for NHHG (9.8% vs 5.0%, p<.0001) with longer lengths of stay (11.5 vs 6.3 days, p<.0001). The greatest predictors of inpatient admission included respiratory failure (OR=17.6, p<.0001), infection (OR=8.6, p<.0001), malnutrition (OR=7.1, p<.0001), and epilepsy (OR=4.5, p<.0001). CONCLUSIONS: Although HHG and NHHG are both characterized by decreased production in antibodies, many differences exist in the characteristics and comorbidities between these patients. Furthermore, hospital resource utilization varies across these cohorts.