OBJECTIVES:  To identify differences in health-related quality of life (HRQoL) domains between survivors of myocardial infarction (MI) and propensity score matched controls. METHODS: This retrospective, cross-sectional study examined HRQoL differences between survivors of MI and propensity score matched controls using data from the 2013 Behavioral Risk Factor Surveillance System (BRFSS) survey. The study sample consisted of adults aged 50 or older who: (i) completed the BRFSS survey, and (ii) reported data on HRQoL. Adults that reported they had ever been told they had an MI formed the case group and those who did not formed the control group. Propensity scores were generated using logistic regression based on gender, race/ethnicity, age, smoking status, and body mass index (BMI). Each case was matched to three controls (1:3) to increase the power of the analyses. Univariate analyses were conducted using chi-square tests before and after propensity score matching. Multivariable analyses were conducted to identify HRQoL differences between groups. Life satisfaction, sleep quality, and activity limitations were estimated using binary logistic regression. Social support, general health, physical health, and mental health were estimated using multinomial logistic regression. Significance was set at p < 0.05. RESULTS:  The final sample consisted of 23,282 survivors of MI matched to 69,846 controls (n=93,128). Compared to controls, survivors were 3 times more likely to report fair/poor general health (Adjusted Odds Ratios (AOR)) = 3.06, 95% CI:2.769-3.396) and 1.7 times more likely to report daily activity limitations (AOR = 1.69, 95% CI:1.56-1.84). Survivors reported poorer physical health (AOR = 2.07, 95% CI:1.88-2.28) and poorer mental health (AOR = 1.56, 95% CI:1.35-1.80). There was no difference between groups in level of emotional support, sleep quality, or life satisfaction. CONCLUSIONS:  Survivors of MI experienced lower HRQoL on domains of general health, physical health, and mental health compared to propensity score matched controls.