Objective: A number of recent treatment advances have been labelled cures but a consistent definition of cure does not exist in research or clinical practice. Further, no single framework exists that can capture key factors in the evaluation of medical technologies and cures. Our objective was to develop a general framework for characterizing the health impact of medical products that can cover high impact technologies and cures Methods: We performed a systematic literature review to identify uses of the word cure in five high burden disease areas: heart disease, human immunodeficiency virus, diabetes, depression, and cancer (prostate and breast). We then applied Walker and Avant’s concept analysis to identify key factors contained within cure definitions. We then developed a comprehensive framework that captures key factors related to a medical technologies’ clinical and economic impact and which includes curative technologies. Results: The key concepts that we identified were: 1) clinical impact, which could be measured using the QALY shortfall or proportional QALY shortfall, 2) economic impact, which can be measured as the incremental net total costs and 3) the timing of the clinical or economic impacts. The key factors that are captured in the framework are: disease burden alleviated, net incremental treatment costs, timing of clinical effects and costs, and the distribution of clinical and economic outcomes for the target population. Conclusions: We developed a comprehensive framework that captures the key factors in the evaluation of medical technologies and cures. The framework can be used to illustrate an individual technology’s impact relative to an alternative as well as facilitate comparative evaluations across technologies.