OBJECTIVES: The Federal 340B drug discount program provides access to significant drug price discounts for healthcare organizations serving disadvantaged patients. Currently there are no published studies documenting pricing trends in the 340B program. In this project, we analyzed drug price trends in the 340B program over a 10-year period. METHODS: Pharmacy purchase records were collected from a 340B-contracted pharmacy system in Los Angeles between 2006 and 2016.Data, including 340B drug price and average-whole-sale price (AWP) were analyzed chronologically to display the price change. Annual average prices were weighted by purchase volume in each year. The results were categorized by American Hospital Formulary Service (AHFS) Therapeutic Classification. All dollar values were reported in 2016 terms. RESULTS: