OBJECTIVES: The aim of study was to describe the change in Disease Activity Score 28 (DAS28) in patients with rheumatoid arthritis (RA) receiving only conventional treatment under a patient centered care model (PCC) in a specialized rheumatology center. METHODS: We carried out a retrospective review of clinical records of patients with RA and treated with conventional treatment in a rheumatology center in Colombia. Patients were followed-up during 24 months using a treat-to-target strategy (T2T); a PCC model means that a patient should be seen by rheumatologist, physical and occupational therapist, physiatrist, nutritionist and psychologist, at least three times a year according to disease severity. Clinical follow-up was according to DAS28: every 3-5 weeks (DAS28 > 5.1), every 7-9 weeks (DAS28 ≥ 3.1 and ≤ 5.1), and every 11-13 weeks (DAS28 <3.1). Patients were classified into four groups due to DAS28: Remission (REM), low disease activity (LDA), moderate disease activity (MDA) and severe disease activity (SDA). Statistical analysis was done. RESULTS: A total of 968 patients were included, 80.2% were women; average age was 63 years (SD 10.7). Regarding conventional treatment, 52.4% received methotrexate, 26.0% leflunomide and 21.6% other DMARDs. At 24 months follow-up, an improvement was observed. At baseline 41% of patients were in remission, 17% in LDA and 42% in MDS/SDA. At the month 24 of follow-up, 66% were in remission, 18% in LDS and 16% in MDS/SDA. Regarding to DAS28, the mean at the beginning of the time analysis was 3.1 (SD 1.0) and after 24-months it was 2.4 (SD 0.7), showing a statistically significant improvement (p <0.000). CONCLUSIONS: We observed a global improvement of DAS28 in patients receiving only conventional therapy, followed under T2T strategy and a PCC model. Those results should be used by decision makers in order to do cost-savings for health systems.