OBJECTIVES:  To perform a cost-effectiveness analysis of solid organ transplants carried out in a private philanthropic hospital in Brazil. METHODS:  For cost analysis we included all patients that underwent kidney, liver, heart and lung transplants in 2015 in our Hospital. We collected data about costs per patient including the pre transplant phase (eligibility evaluation for the transplant, listing and outpatient follow up), the transplant and post-transplant phases until 1 year of follow up. Unit costs were associated to each health resource, obtained from the hospital costing system. For the survival analysis we used Cox model, using all the transplants performed from 2002 to 2016 in our institution. For the cost-effectiveness analysis we used the following calculations: 1. Calculation of average cost for each year of life = (average total cost/mean survival time); 2. Calculation of lifespan in years for the repayment of the transplant by the recipient = (average total cost /GDP per capta); 3. Calculation of wealth production after the transplant [(mean survival time)–(average total cost /GDP per capta)*GDP per capta]. The values of GDP per capta and dollar exchange rate were the ones from 12/2015, being U$ 6.963,94 and BRL 3,91, respectively. RESULTS:  All types of transplant analyzed here were cost-effective; all of which had a cost of life saved per year less than 3x GDP and the dialysis treatment cost. Considering all of them together, there will still be a wealth production after paying off the treatment, in mean of U$ 32,672.67. CONCLUSIONS:  In a private Hospital, where the Transplant Program is funded by the Public Health System, kidney, liver, heart and lung transplants were considered cost-effective therapies. This analysis can support our Hospital Managers and transplant teams to take the best decision in an era of growing chronic diseases.