COMPARISION OF HEALTH UTILITY MEASURES FOR AMYOTROPHIC LATERAL SCLEROSIS IN THE GENERAL KOREAN POPULATION- STANDARD GAMBLE AND EURO QOL-5D
Author(s)
Kim J, Lee S, Lee S, Lim SJ, Suh D
Chung-Ang University, Seoul, Korea, Republic of (South)
Presentation Documents
OBJECTIVES: To elicit health utilities for health states of amyotrophic lateral sclerosis (ALS) in the general population of South Korea using standard gamble (SG) and Euro-quality of life five dimensions questionnaire (EQ-5D) as well as to identify the factors which cause differences in the two utility measures. METHODS: Four ALS health state descriptions according to disease severity were developed: mild, moderate, severe, and terminal state. Utilities of these states were measured via SG and EQ-5D from 202 respondents, who were selected using a stratified quota sampling method to represent the general Korean population. Utility values for each health state were compared using paired t-tests, and the relationships between the two utility measures and levels of disease-severity and sociodemographic factors were tested using generalized estimating equations. RESULTS: When disease severity increased, both SG and EQ-5D showed systematic decreases. The utility values between SG and EQ-5D for each state, excluding the mild state, were significantly different: utility value for mild 0.880±0.101 vs. 0.877±0.053 (p=0.716); moderate, 0.787±0.154 vs. 0.722±0.092 (p<0.000); severe, 0.629±0.186 vs. 0.446±0.186 (p<0.000); terminal 0.346±0.206 vs. 0.014±0.144 (p<0.000). The differences in utility values between SG and EQ-5D in health states progressively increased as patients' health states became more deteriorated. The differences in utility for moderate, severe, and terminal state were 1.06, 1.20, and 1.36 times greater, respectively, compared to that of mild state. The differences in utility were 7% higher in women than men (p=0.02). CONCLUSIONS: The study found that utility values of SG were significantly higher than those of EQ-5D. In addition, the difference between SG and EQ-5D gradually increased as patients’ health became severe, implying that general population was risk averse. It is recommended that a future study be performed to find the causes of the differences between utility derived from SG and EQ-5D in the Korean population.
Conference/Value in Health Info
2017-05, ISPOR 2017, Boston, MA, USA
Value in Health, Vol. 20, No. 5 (May 2017)
Code
PND48
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities
Disease
Neurological Disorders, Rare and Orphan Diseases