OBJECTIVES: :  To (1) determine whether Conscientiousness or Agreeableness was associated with different treatment outcome preferences and (2) examine whether the choice between Dead and moderate or severe health differed by levels of personality traits. METHODS: An online survey was administered to a convenience sample of doctoral pharmacy students. Respondents completed a personality inventory to measure levels of Big Five personality traits (Extraversion, Agreeableness, Conscientiousness, Emotional Stability, and Openness to Experience), then categorized by tertiles (low, moderate, high) for each trait. Treatment outcome preferences were quantified using profile-based (case 2) best-worst scaling (BWS) where profiles were described using the EQ-5D-Y descriptive system and framed with a hypothetical cancer scenario. In two additional items, respondents were asked to choose between Dead and moderate and severe health states. Count analysis obtained preference scores for each treatment outcome. Analysis of variance (ANOVA) and Kruskal-Wallis test (KWT) examined preference differences across Conscientiousness and Agreeableness tertiles. Logistic regression models evaluated the association between higher levels of Conscientiousness and Agreeableness and choosing Dead over the moderate and severe health states. RESULTS: : A total of 185 respondents were recruited. Preferences were significantly different across Conscientiousness tertiles for “no problems” in Usual Activities (ANOVA p=0.03, KWT p=0.06), Pain/Discomfort, and “a lot of problems” in Pain/Discomfort (p-values <0.05). No differences in treatment preferences were observed across Agreeableness tertiles. Higher levels of personality traits were not significantly associated with choosing Dead over moderate health (Conscientiousness: odds ratio [OR] 3.9, 95%CI 0.4-34.7; Agreeableness: OR=0.2, 95%CI 0.02-1.7); nor severe health (Conscientiousness: OR 0.8, 95%CI 0.4-1.6; Agreeableness: OR 0.7, 95%CI 0.3-1.3). CONCLUSIONS: Conscientiousness appears to be a factor in treatment outcome preferences among future pharmacists. Conscientiousness and Agreeableness may impact choosing Dead over health states based on the effect magnitude; however, larger studies are needed to confirm this association.