ASSOCIATION OF CLINICAL COMPLICATIONS AND SURGERY TREATMENT ON RECURRENCE OF ACUTE DIVERTICULITIS

Author(s)

Kawatkar AA1, Chu L2, Nichol MB3
1Kaiser Permanente Southern California, Pasadena, CA, USA, 2Analysis Group, Inc., Los Angeles, CA, USA, 3University of Southern California, Los Angeles, CA, USA

OBJECTIVES:  To evaluate the association of demographic factors, clinical complications and surgical management of diverticulitis with its recurrence. METHODS:  We identified all adults (18+ years) who had acute diverticulitis (incident cases) during 01/01/2007 to 12/31/2011 from the Kaiser Permanente Southern California Health Plan. Prior to diagnosis of the incident event (index date), the patients were required to be a health plan member continuously enrolled for ≥ 12 months (baseline period) without evidence of diverticulitis. We defined recurrence as a patient meeting case definition ≥ 30 days after the index date. Through chart review, we captured the following complications during the incident presentation: abscess, intestinal obstruction, pneumoperitoneum, fistula, and peritonitis. Lastly, we identified patients who had colon surgeries within 30 days of the index event. A stratified (by sex) cox proportional model was specified with sociodemographics, Elixhauser comorbidity, clinical complications and surgical management to evaluate the hazard of diverticulitis recurrence. RESULTS:  We identified 33,442 incident cases: 58% female; 68% white. Mean age (mean ± SD) in females was 61 ± 14 years while in males it was 56 ± 15 years. During a mean (median) of 46 (49) months follow-up, 11,092 patients had a recurrence. In females, the hazard of recurrence increased with complication of abscess (Hazard ratio; (95% CI) 1.4; (1.2 to 1.7)) while surgery reduced the recurrence hazard (0.7; (0.6 to 0.8)). In males, the hazard of recurrence increased with presentation of pneumoperitoneum (1.3; (1.1 to 1.5)) and abscess (1.6; (1.3 to 1.9)) while it decreased with findings of intestinal obstruction (0.6; (0.4 to 0.9)) and with surgery (0.5; (0.4 to 0.7)). Recurrence hazard significantly increased with age in females while it significantly decreased with increasing age in males. CONCLUSIONS:  We identified significant heterogeneity in the hazard of diverticulitis recurrence by presenting complications and by age, between the sexes.

Conference/Value in Health Info

2017-05, ISPOR 2017, Boston, MA, USA

Value in Health, Vol. 20, No. 5 (May 2017)

Code

PGI12

Topic

Epidemiology & Public Health

Disease

Gastrointestinal Disorders

Explore Related HEOR by Topic


Your browser is out-of-date

ISPOR recommends that you update your browser for more security, speed and the best experience on ispor.org. Update my browser now

×