OBJECTIVES: This study aimed to measure and analyze EQ-5D derived population norms for Pakistani general population by demographic characteristics. METHODS: A cross-sectional nationwide study was conducted. Population sample (n = 16672) was selected from Federal Territory, Punjab, Sindh, Khyber Pakhtunkhwa, Balochistan, Azad Jammu and Kashmir and Gilgit Baltistan by using stratified sampling approach. The EQ-5D tool was used to measure health-related quality of life (HRQOL) of healthy population of Pakistan by socio-economic demographic characteristics. The descriptive and inferential statistics have been done by using SPSS version 20. RESULTS: A total of 121 health states reported by the respondents. EQ-5D descriptive score and EQ-VAS score were 0.74 ± 0.32 and 0.75 ± 0.25 respectively. The percentage of people responding to any problems in the five EQ-5D-3L dimensions increased with age and males have better health as compared to female in all age groups. Comparison of mean score and inferential statics shown all demographics were significantly associated (P<0.01) with mean EQ5D score and VAS except residence (p>0.05). Regression model reported Age, City, Gender, Education, Occupation, Residence and House occupancy significantly associated with HRQOL. However, house occupancy (Beta= 1.745) and Age (Beta= 1.1331) were rated as predictors of HRQOL in the current cohort. CONCLUSIONS: This study provides Pakistani population HRQOL data measured by the EQ-5D tool, based on a national representative sample. Current study concluded that health status Population norms are useful in making health status of general persons of Pakistan. Socioeconomically deprived groups have inferior health status than more advantaged. The trends detected in high income nations were usually similar to the Pakistan.