OBJECTIVES: to assess and compare the health related quality of life (HRQoL) among diabetics, pre-diabetics and general population in China METHODS: Questionnaire was designed and pre-tested which included 2 parts: Sociodemographic information and EQ-5D-5L with VAS. Face-to-face survey was conducted to sampled 420 diabetes patients from tertiary hospitals in sichuan China and 420 general people from communities and parks(exclude people who claimed diabetes)； telephone survey was conducted to 420 sampled people who took physical examination in tertiary hospitals in the past 2 months and found intermediate hyperglycaemia. Differences between groups were compared by chi-square test,one-way analysis of variance (ANOVA) ,Kruskal-Wallis test or student's t test. RESULTS: Effective information of 403 diabetics, 404 prediabetics and 398 general people was collected. The average age of sampled diabetics was 62.18±11.3 with mean BMI 24.57±4.05 kg/m, the average age of pre-diabetics was 53.29±9.21 with mean BMI 23.73±2.99 kg/m, and the average age of general population was 58.94±12.48 with mean BMI was 23.67±4.24kg/mCONCLUSIONS: There was a general decline trend of HRQoL and all 5 dimensions from general people to diabetes patients, while pre-diabetics had better HRQoL than general people. The common self-assessed problematic dimensions among 3 groups were pain/discomfort and anxiety/depression, and the status of pain/discomfort was worse than anxiety/depression. Further and larger longitudinal studies are needed to confirm these findings.