OBJECTIVES:  Tuberculosis is one of the oldest infections known to affect humans. The aim of the study was to assess the quality of life including physiological, general health perception and social role functioning among patients with tuberculosis in Govt.Infectious Disease Hospital, Guntur. METHODS:  Total 180 Tuberculosis patients with tuberculosis who registered were included in the study by using multi stage sampling method From DOTS Centre we had taken 10 Sputum positive newly diagnosed, 6 category II (2 for each defaulter, relapse, failure), 2 MDR and 2 HIV patients. We excluded pediatric patients. Thus, a total of 180 cases were interviewed using a pre-designed, pre-tested questionnaire. Socio-demographic data, perception about the Quality of Life (QoL) was collected using RAND-SF 36questionnaire. RESULTS:  Mean age of cases was 33.3+11.7years and 124 (68.9%) were male and 56(31.1%). The mean score of all domains was 53.4 with SD of 11.2.The worst affected domains were vitality (44.6 +13.8), general health (45.7+ 18.7) and mental health (47.7 + 16.6). MDR patients had lower mean score for physical health (56.3 + 15.2), vitality (35.8 + 13.5) and pain (46.3 + 16.1) as compared to other TB category patients. Mean score of social function (43.6 + 13.8), emotional role (37.1 + 27.9) and emotional wellbeing (38.3 + 13.7) were lower in TB with HIV patients. In all domains female have better scores except two domains, which are emotional health and social function CONCLUSIONS: We recommend that early diagnosis and treatment decrease severity and infectivity to other person and improve QoL. Health education during diagnosis and family support may reduce social stigma and improve the mental component of QoL.