OBJECTIVES: "De Todo Corazón" (DTC) is a risk management program with the aim of reducing complications and improving the quality of life of patients with cardiovascular risks. The aim of this study was to assess the prevalence of cardiovascular risk factors in patients under program care. METHODS: The study comprised individuals (64,668) of all ages, living in the Colombian Caribbean. Data on anthropometric parameters, blood pressure, glycosylated hemoglobin, total, low-density (LDL) and high-density (HDL) lipoprotein cholesterol, triglycerides, physical activity and smoking status were collected of the program database. We used the risk classification of Framingham Heart Study. RESULTS: The average age was 64.5 + 13.9 years and 66.5% female. The overall prevalence rates were as follows: hypertension (ICD-10 hypertension code or >140/90 mm Hg or pharmacologic treatment), 96.5% (96.3%-96.6%); hyperlipidemia (total cholesterol >240 mg/dl or triglycerides >200 mg/dl or LDL cholesterol >100 md/dl or HDL cholesterol), 85.2% (84.8%-85.4%); diabetes (ICD-10 diabetes code or pharmacologic treatment or glycosylated hemoglobin >6.5%), 36.1% (35.7%-36.5%); metabolic syndrome, 6.3% (6.1%-6.5%); obesity (body mass index >30 kg/m), 43% (42.6%-43.4%); smoking, 2.2% (1.9%-2.2%); and physical inactivity, 77.8% (77.5%-78.2%). 80% of the patients had data necessary for the classification of cardiovascular risk. 34.9% of the patients had a high cardiovascular risk according to the classification of 80% of the patients had data necessary for the classification of cardiovascular risk. 34.9% had a high cardiovascular risk according to the classification of Framingham Heart Study. CONCLUSIONS: The hypertension, hyperlipidemia and physical inactivity was highly prevalent in patient under program care. One-third of patients had a high cardiovascular risk according to the classification Framingham Heart Study.