OBJECTIVES:  Insights from real-world/health-economic (RW/HE) research are becoming increasingly important to clinical decision-making in a number of therapy areas. This study quantifies the publication of RW/HE evidence in clinical journals over ten years (2005–2015) and across different therapy areas. METHODS:  Five therapy areas were selected: cardiology, diabetes, neurology, oncology, and nephrology. Within each therapy area, three journals were identified based on impact factor (high) and clinical editorial focus. For these journals, a literature analysis was performed using EMBASE to identify published RW/HE original research articles – as defined by ISPOR – using a search string based on previously published recommendations. We used chi-square tests to compare the proportion of RW/HE articles grouped by therapy area in 2005, 2010, and 2015, and pair-wise tests to compare changes from 2005–2010 and 2010–2015. We also compared the proportion published in society journals versus non-society journals. RESULTS:  Among all therapy areas, the proportion of RW/HE publications increased over time, but especially during the period 2010–2015. Overall, the proportion of RW/HE publications increased from 6.6% in 2005 to 9.0% in 2010 and 17.1% in 2015 (p<0.001). The proportion of RW/HE publications was different between therapy area (p<0.001 in all 3 time points), with the highest proportion in 2015 for diabetes (23.3%), cardiology (21.0%), and nephrology (20.1%), and the lowest for neurology (8.4%) and oncology (11.7%). Compared with non-society journals, society journals published a higher proportion of RW/HE publications (5.9% vs 20.1% in 2015; p<0.001) and had a stronger increase over time (growth rate 74.3% vs 99.9% for 2010–2015; p<0.001). CONCLUSIONS:  During the period 2005–2015, the proportion of RW/HE articles in top clinical journals increased across all therapeutic areas investigated. These results could suggest an increasing willingness to publish RW/HE evidence for health-care decision-making, with some notable differences between therapy areas.