OBJECTIVES:  Medication non-adherence can limit the full realization of treatment benefits for patients. Numerous factors account for non-adherence, including various reasons reported by patients via the Medication Adherence Reasons Scale (MAR-Scale). The current objective was to revise the MAR-Scale to extend its scope to various comorbid conditions across modes and frequencies of administration. METHODS:  The MAR-Scale items and presentation were adapted in collaboration with input from patients, healthcare professionals, researchers, and survey programmers, to accommodate different modes and frequencies of administration and up to 17 comorbid condition groups (including arthritis, diabetes, and pain). The presentation and programming were modified with the intention of engaging respondents and minimizing fatigue/burden, while encompassing the broader scope. RESULTS: The original MAR-Scale was reorganized into an online grid format where each item is answered across conditions (adjacent columns). Respondents enter a number within a valid range for each item within a condition, instead of selecting among predetermined response option boxes. Respondents are asked about any prescription medication(s) taken per condition, albeit broken out by administration mode (oral, topical, self-injection) and frequency (daily, weekly). MAR-Scale items were revised to accommodate the different modes; similarly, response options were adapted with respect to past 0-7 days for daily use (as per the original) or 0-4 weeks for weekly use. Mode (3) by Frequency (2) combinations result in up to six MAR-Scale grids completed separately. Introductory instructions were modified to highlight the focus of each version. The modified MAR-Scale will be administered to approximately 20,000 participants for further testing, revision, and validation. CONCLUSIONS:  The original, treatment-specific MAR-Scale was adapted to provide real-world data across various conditions and modes and frequencies of administration (for each patient). This revised measure allows for a broader assessment of patients’ treatment experiences and challenges, thereby helping inform more programmatic interventions intended to improve adherence within and across conditions.