OBJECTIVES: "De Todo Corazón" (DTC) is a risk management program with the aim of reducing complications and improving the quality of life of patients with cardiovascular risks. The aim of this study was to compare to evaluate the clinical goals of blood pressure control, metabolic control, weight control and lipid control in patients under program care. METHODS: We started follow-up of a cohort of 64.668 patients with hypertension and/or diabetes mellitus between June 2014 and December 2015. Clinical goals of blood pressure control (<140/90 mmHg), metabolic (HBA1C <7.5%), weight control (BMI < 30 kg/mts) and lipid (LDL <100 mg/dl) were established. RESULTS: The average age was 64.5 + 13.9 years and 66.5% female. In 18 months of follow-up and independent of the number of medical controls and activities of risk management program, between 73% and 80% of patients achieved good blood pressure control; Between 6.8% and 36.7% achieved good metabolic control; 54% had good weight control; and 68% achieved good lipid control. CONCLUSIONS: The results in the clinical goals suggest a positive impact on the cardiovascular risk of patients under program care. Less effective was shown for weight control and metabolic control suggesting that new approaches should be undertaken to improve the results of the program.