OBJECTIVES:  To investigate A1C levels among patients with diabetes mellitus (DM) in the US and understand factors associated with glycemic control. METHODS:  This cross-sectional analysis utilized National Health and Nutrition Examination Survey data (2011-2014) and evaluated A1C levels and factors associated with glycemic control among patients with DM via multivariate logistic regression. Chi square and t-test were used to compare patient characteristics between A1C level groups (<7% vs. ≥7%). Eligible predictors (p<0.2) were included in a multivariate logistic regression model to determine the association between glycemic control and patient characteristics. RESULTS:  Of the 1,326 patients identified with DM from 2011-2014 (mean age 61.2 years; 49.8% female), half (50.2%) achieved the American Diabetes Association (ADA) A1C target of <7%. Similarly, 60.9% and 54.3% of patients with DM achieved blood pressure (<130/80 mmHg) and lipid targets (<100mg/dL), respectively. Bivariate analysis suggested that age, gender, ethnicity, health insurance status, body mass index (BMI), and time since DM diagnosis were significantly associated with A1C level. After adjusting for covariates, patients with DM who were female, older, insured, non-Hispanic whites with a BMI from 25.0 to 29.9 and a recent DM diagnosis (<5 years) were more likely to meet the ADA A1C target of <7%. CONCLUSIONS:  The current study highlights the importance of integrated, comprehensive DM care, given that almost half of patients with DM still do not achieve A1C, blood pressure, or lipid target levels suggested by ADA guidelines.