In the present scenario, the health of Homo sapiens is drastically deteriorating due to man’s desire for rapid industrialization and urbanization. The heartwarming conditions like cardiovascular disease remain the world’s main cause of mortality and are linked to high blood cholesterol and chronic low grade inflammation. The emerging trends of multidrug resistance among several groups of microorganisms against different classes of antibiotics led to use of probiotics for cholesterol lowering has been extensively studied and is considered a prospective option to prevent cardiovascular diseases like pickwickian syndrome which is also known as the Obesity hypoventilation syndrome (OHS). The use of probiotics for cholesterol lowering has been extensively studied and is considered a prospective option to prevent cardiovascular disease. In this study we report the causes of Pickwickian syndrome,clinical safety and efficacy of cholesterol lowering probiotics like Lactobacillus reuteriand other strains. KEYWORDS: Cardiovascular disease, biotechnology, probiotic , Lactobacillusreuteri,Obesity Hypoventilation Syndrome (OHS)