OBJECTIVES: Diagnostic images and reports are essential to diagnose a wide range of conditions and diseases. Experience at individual treatment centers is limited and research efforts are often fragmented, and, furthermore, patient series are relatively small, even at multicenter level. In such setting central review of diagnosis and treatment is frequently offered in order to evaluate difficult cases. METHODS: Cineca developed a secure web-based platform in collaboration with representatives from several Pediatric Oncology International Associations (SIOPEL, GPOH, COG, and JPLT). The efforts were supported by a grant from FP7 EU-funded Project ENCCA (European Network for Cancer Research in Children and Adolescents). The platform named Virtual Consultation System is an innovative tool aimed to collaborative review clinical cases with the possibility to share images in high quality, providing a tool for easily transfer files of big size. RESULTS: The web systemsupports researchers in management of complex clinical cases through online consultations among experts world-wide and integrates tools for Tumor Board review.  Consultation process is completely managed through structured data (e-CRFs) and final opinion is sent back to the requesting physician through the platform. Patient data and images are stored electronically  in a database through a secure web infrastructure for research/training/elearning and the platform includes an integrated DICOM browser for radiology and virtual microscope for pathology without quality loss. The tool is also fully integrated with a videoconferencing system. The main output is a report containing the collective findings, conclusions and recommendations for the further treatment of the patient. CONCLUSIONS: Virtual Consultation System can be considered a very valuable tool for case consultation and tumor board where clinicians need to share expertise and get consultation from other colleagues in different areas of the world in order to facilitate access to the best expert care to all children with cancer or rare disease in Europe without travelling