OBJECTIVES: To validate a multi-disease- specific instrument: the Diabetes, Hypertension, and Dyslipidemia Survey (DHDS) developed using mixed methods.  METHODS: Validation was conducted using pre-post-intervention with historical control design, on a sample drawn from a pharmacist-managed diabetes education clinic. The DHDS consists of 22 items measuring extent of limitation (with 6 questions addressing change in the post-intervention survey) on a 4-point agreement scale. Items correspond to 6 HRQL domains: physical functioning, social functioning, diet, emotional well-being, medication-related issues, and general well-being.  Participants were recruited if they were at least 18 years old and newly enrolled in the clinic. Pre-survey was given at the first visit followed by an educational intervention, and post-survey was administered 3-6 months later. Pre-post scores were tabulated per domain. Internal consistency of the tool was assessed using Cronbach’s alpha. Pre- and post-A1C were also collected to examine the clinical impact of the intervention. Analyses were conducted at Alpha of 95%. RESULTS: Total of 22 participants completed pre- and post-surveys. Mean age was 60.4 (SD = 11.8), and more than half (54.5%) the participants were male. Missing data was higher than 5% only for the medication domain (68%). Although not statistically significant, there was a general trend of improved mean HRQL from the pre- to post-survey except the medication domain, possibly due to education by the pharmacist. The pre-survey domain means ranged from 1.8 to 2.6 with higher score indicating higher disease burden. Internal consistency was good in both pre- (0.911) and post-surveys (0.742). Although A1C was available for only a small subgroup (n=6), the decrease from mean pre (7.4) to post (6.6) was significant (p<0.05). The small sample size precluded factor analysis for domain validation.  CONCLUSIONS: The DHDS Tool demonstrated acceptable reliability but needs testing with a larger sample size for further validation.