OBJECTIVES: Surgical site infections (SSI) impose a heavy burden to healthcare systems due to additional hospital resource utilization, the negative consequences for patients and the impact in hospital’s quality performance. Triclosan-coated sutures (TCS) have shown a significant reduction in SSI risk. The objective of this study was to estimate budgetary outcomes of a TCS-adoption strategy for wound closure in selected surgical procedures vs. non-coated sutures under the Mexican public healthcare system perspective. METHODS: A budget impact model was developed to estimate TCS-adoption cost implications for the public healthcare system in Mexico in coronary artery bypass graft (CABG), joint replacement (JR) and surgical colorectal (CR) procedures. Procedure-specific annual volume was internally estimated. Procedure-specific SSI rates and TCS-associated SSI risk reduction were taken from published international evidence and used to compute annual SSIs. An average number of sutures per procedure were assumed based on current clinical practice. Cost data for comparators and TCS were internally set at market value. A specific DRG from a public healthcare institution was used as proxy for SSI treatment cost. Considered time horizon was less than one year, thus no annual discount rate was used. No pediatric population nor mortality was considered. Results are shown in 2015-adjusted USD.  RESULTS: TCS adoption would yield savings for $2.9, $5.2, and $22.7 million for CABG, JR and CR, respectively, while avoiding 73, 147, and 486 infections out of 5,900, 27,300, and 17,600 CABG, JR and CR procedures. Higher unitary costs for TCS are offset by significant savings due to SSI risk reduction. Breakeven point to offset the current practice was reached at 4.7%, 8.1% and 1.1% SSI risk reduction levels for listed procedures. CONCLUSIONS: Under provided scenario, TCS adoption in selected procedures could yield relevant benefits for the Mexican public healthcare system, with savings for payers and benefits for hospitals & patients.