OBJECTIVES: The informal sector accounts for over three-quarters of the economies of developing countries and host varying socio-economic activities. Due to unorganised nature of these activities, there is high likelihood of incidence of injuries and disabilities. However empirical evidence of these in the informal sector remains scanty. This paper examines the incidence and risk factors of occupational injuries and disabilities in the informal sector of Kumasi, the second largest city of Ghana, METHODS: A cross-sectional study was conducted with randomly selected 1288 auto mechanics to quantitatively estimate the incidence and risk factors of occupational injuries and disabilities at the Tafo-Suame magazine in Kumasi. Data were summarized into descriptive and inferential statistic in STATA version 11 with statistical significant level set at 5%, 95% confidence interval,RESULTS: The sex injury ratio was 9:1 in favour of males. Injuries were found in all the varying occupations. Out of the 1,285 respondents, 619 representing 47.9% (95% C.I. [45.2%, 50.6%] had injury person working hour in the past 12 months. There were 82.1% minor injuries and 17.9%, major injuries. The site and type of injury were bruise on hands, 28.4%, cuts on hands, 4.4%, cut on head, 5.7% and eye 9.4%.   The risk of injury increased significantly with pushing (OR=3.1, p<0.001), lying down (OR=3.7, p<0.001), and run (OR=7.0, p<0.001) compared with sitting while working. Stretching part of the body while working had a 20% reduced risk (OR = 0.8, p=0.69) of injury as compared to sitting, CONCLUSIONS: The incidence of injury among informal sector auto mechanics is close to 1 in 2 person working hour with 8% disability while pushing, postures, lying down, and running are the risk factors. These have policy implications for injury prevention and control programmes.