OBJECTIVES: This study aimed to assess the prevalence of the types of Drug Resistance TB in patients attending Fatima Jinnah TB Sanatorium in Quetta. METHODS: A retrospective study was conducted to assess the assess the prevalence of TB types in patients who attended Fatima Jinnah TB Sanatorium, the only tertiary care unit in Balochistan for the treatment of patients suffering from TB. Data was collected from patients of TB sanatorium that came for. treatment to hospital between 2014 and 2015. Data was collected of patients files and arranged into domains. Collected data was fed into Microsoft Excel and analyzed to determine the most prevalent type of MDR TB RESULTS: The total number of registered patients of DR-TB during study period were 225. Out of which majority of patients 42 (33.3%) were belongs to age group 21-30 years, and female gender was dominating (n=139, 61.7%). The patients were classified into CAT-1 (new cases) were 123 (54.6%) patients while CAT-2 (relapse) 78 (43.66%) patients were reported. MDR plus (n=55, 24.44%) Furthermore, DR-TB patients were categorized into MDR-TB (n= 152, 67.5%), XDR-TB (n=9, 4%), Mono (n=2, 0.9%), Poly (n=7, 3.1%), was MDR type TB.  CONCLUSIONS: This study concluded that the cases related to DR TB are increasing in population. Furthermore, newly diagnosed patients are having drug resistance TB which is an alarming situation and efforts should be made to reduce not only the spread of infection n society but also the proper treatment of existing TB patients should be done to avoid cases of drug resistance.