OBJECTIVES: In Ukraine there is an urgent need for rational allocation of scarce resources and priority settings in health care in the current economic situation. The study aims to examine and outline actual issues of HTA system implementation in Ukraine. METHODS: A review and expert interviews were conducted towards the key stages of implementation of HTA system in the recent years in Ukraine. RESULTS: There is no central national HTA agency currently functioning in Ukraine. Simultaneously, some HTA-related procedures are applied for the development of State Drug Formulary and national treatment protocols. Non-governmental organization (NGO) UA HTA and representatives of academia are facilitating the process of HTA implementation in real-life practice for the decision making process. In the recent years, the articles on HTA introduction, methodical recommendations for postgraduate studies were published by Ukrainian scientists. In 2013-2014 the capacity building and training courses on HTA were carried out by NGO UA HTA in collaboration with foreign colleagues. The Commission on development of HTA system of the MOH works on the introduction of HTA since 2014. We propose the implementation of “light” model of HTA in Ukraine: HTA reports have to be prepared by applicant for reimbursement, minimal use of public funds will provide high performance of HTA reports and high value of HTA in health care policy, national HTA agency have to become a “goalkeeper” while providing critical appraisal of HTA reports. National HTA Guidelines have to be approved within legal framework. Adaptation of international HTA reports to local environment is of high importance.  CONCLUSIONS: Importantly, in the next years there is a necessity to implement international requirements to HTA in order to prioritize procurements of medicines, their financing by government, reimbursement decisions in order to improve the market access, medicines prescription and patients’ health outcomes according to the developed scientific methodology in Ukraine.