INSULIN AND HIGHER ODDS OF A POSITIVE HISTORY OF CARDIOVASCULAR DISEASE AMONG DIABETIC INDIVIDUALS
Author(s)
Geneus CJ, Davis RE
Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Presentation Documents
OBJECTIVES: This study examined associations between positive history of cardiovascular disease (CVD) and insulin, socio-demographic, and psychological determinants among diabetic respondents. METHODS: Data from the 2014 Behavioral Risk Factor Surveillance System (BRFSS) were analyzed for 9,506 self-reported diabetic survey participants aged ≥18 years. Both weighted multivariable and multinomial logistic regression models assessed history of CVD. RESULTS: CONCLUSIONS: Self-reported diabetic individuals who use insulin had higher odds of a self-reported history of CVD, particularly CHD. Future research should determine whether other medical and cardiometabolic mechanisms interact with insulin to better understand CVD outcomes.
The adjusted multivariable model revealed that the odds of a positive self-reported history of CVD were 1.43 (95% CI: 1.22-1.68) times higher among individuals who reported using insulin compared to non-users. Older individuals (aged ≥ 55 years) had higher odds (aOR = 2.72; 95% CI: 1.30-5.67) of history of CVD compared to younger peers (aged 18-24 years). Furthermore, males had higher odds compared to females (OR = 1.35; 95% CI: 1.15-1.60). Interestingly, alcohol users had 21.2% (aOR = 0.79; 95%: 0.66-0.95) lower odds compared lifetime abstainers. Although positive self-reported frequent mental distress (≥14 mentally unhealthy days) (aOR = 1.11; 95% 0.89-1.39) and depression (aOR = 1.10; 95% CI: 0.91-1.33) both increased the odds of a positive self-reported history of CVD, only self-reported physical health (≥30 days of physical health not good) was statistically significant (aOR = 1.64; 95% CI:1.40-1.93).The adjusted multinomial logistic regression model showed that, compared to individuals without a history of CVD, insulin users had higher odds of self-reporting coronary heart
disease (CHD) (aOR = 1.53; 95% CI: 1.22-1.68). Moreover, insulin users had 8% lower odds of self-reporting stroke, (aOR = 0.92; 95%CI: 0.69-1.24) and had 1.30 times (OR = 1.30; 95% CI: 0.94-1.80) higher odds of self-reporting myocardial infarction but such trend were not statistically significant. Conference/Value in Health Info
2016-05, ISPOR 2016, Washington DC, USA
Value in Health, Vol. 19, No. 3 (May 2016)
Code
PCV7
Topic
Epidemiology & Public Health
Disease
Cardiovascular Disorders, Diabetes/Endocrine/Metabolic Disorders