OBJECTIVES: Changes in payment systems for joint replacements have highlighted the need for hospitals to improve the quality of care while also reducing costs. In this analysis we assessed the relationship between various interventions associated with ERAS and perioperative outcomes such as hospital length of stay (LOS). METHODS: Patients undergoing TKA between July 1, 2013 and March 31, 2015 were identified in the Premier Perspective Hospital Database. The use of ERAS interventions, including early mobilization, non-opioid analgesia, and prophylactic treatment of infections and thromboembolism, was identified from hospital chargemaster codes. Multivariate logistic regression was conducted to examine the impact of these interventions and patient factors (age, comorbidities, race, etc.) on hospital LOS ≤2 days.  RESULTS: