OBJECTIVES: Optimum hemostasis is critical to prevent surgical bleeding progression and the development of associated complications, which imply additional hospital resource utilization. Hemostats such as Surigcel™ Original (SO) have demonstrated to effectively prevent bleeding complications; with improved hemostatic action, newer Surgicel™ versions (Fibrillar & SNoW, SF&S) could potentially yield economic benefits. This study aimed to estimate and compare healthcare costs associated with the use of SF&S vs. SO for selected surgical procedures under a Mexican public hospital perspective.  METHODS: The study aimed to estimate and compare costs attributable to the use of SF&S and SO in carotid endarterectomy (CEA), brain/cerebral (BC), and cardiovascular (CV) procedures in a 3^rd level public hospital in Mexico. Total cost components for each procedure were length of stay (LOS), intensive care unit (ICU) days, hemostatic units and blood transfusion units; no other bleeding-related complications were considered. Resource utilization data for each considered procedure were taken from a recently published retrospective analysis of comparable cohorts using the aforementioned Surgicel™ versions. LOS and ICU costs were taken from official public cost lists, SF&S and SO costs were set internally at market value, and blood transfusion costs were taken from published local evidence. Considered time horizon was less than one year, thus no annual discount rate for costs was used. Results are shown in percentage savings / additional cost per patient. RESULTS: Under the conservative approach considered, SF&S use yielded a 17.2% and 12.6% reduction in total costs vs. SO for BC & CV, respectively; for CEA, SF&S use resulted in 1.8% higher total costs. While new Surgicel™ versions are more costly, their faster times to hemostasis reduce additional LOS and ICU days, being the latter the most significant savings driver.  CONCLUSIONS: Under provided conditions, the use of newer versions of Surgicel™ represents potential savings for public hospitals in Mexico.