OBJECTIVES: Genital warts (GW) cause significant psychological morbidity and substantial healthcare costs.  There is no published data regarding costs of GW in Panamá.  The objective of this study was to describe the patterns of healthcare resource utilization (PHRU) and associated costs in males and females with GW in Panama.  METHODS: We undertook a descriptive study that used a series of questions in a Delphi panel to establish consensus on the PHRUs of GW in Panama.  The panel consisted of 12 experts (gynecologists, urologists and dermatologists) from the Social Security health system in Panama.  The implementation took 5 weeks, during which the panel members received and responded to a structured questionnaire during the first round; received and reviewed data aggregated from all the responses; and responded once more to the questionnaire during a second round.   The questionnaire was based on a series of questions about the resources used in the treatment of GW, taking into account demographic data, diagnostic tests, treatment options, clinical guidelines, adverse events and complications of the current treatments, and number of outpatient visits.  The questionnaire was developed from previously published studies that used a similar methodology. The costs for treatment and care (in US dollars, 2015) were obtained from the public oncology hospital, "Instituto Oncológico Nacional" and from the non-profit health clinic, "Asociación Panameña para el Planeamiento de la Familia". RESULTS: In females the cost per episode of GW was $466.76. The highest costs were seen in laboratory exams ($282.32) and in pharmacological treatment ($166.03).  In males the cost per episode was $365.89. The highest costs were also obtained in laboratory exams ($188.93) and in pharmacological treatment ($163.40).   CONCLUSIONS: These findings underscore the importance of implementing public health initiatives, such as education and vaccination, for the prevention of GW among women and men in Panamá.