OBJECTIVES: Properly switching medication’s route of administration from intravenous (IV) to oral (PO) using equipotent doses, proved to be associated with multiple positive outcomes. With $21k-$450k yearly cost savings per institution, many hospitals have implemented therapeutic interchange programs to facilitate proper conversion. The primary objective of this project is to develop and implement a customized IV to PO conversion protocol at the University Medical Center Rizk Hospital (UMC-RH). Additional objective includes evaluation of the associated potential cost savings from hospital and patient perspectives. METHODS: An extensive literature research was conducted, current practice guidelines were identified. Additionally, the UMC-RH formulary was reviewed to develop patients and medications inclusion criteria. A five-week intervention was carried out, the percentage of patients receiving adequate treatment (via appropriate route of administration) was the primary endpoint. Secondary economic endpoints included the estimated cost saving per patient per day for each of the study medications and the estimated cost savings per dose for proper therapy conversion over the project duration. All data analyses were conducted using SPSS for Windows version 23.0. A p-value of less than 0.5 was considered significant for all analyses. RESULTS: