OBJECTIVES: The aim of the study was to analyse the correlation between Quality of Life and adherence in patients receiving (ART) anti retroviral therapy.  METHODS: It is a prospective observational study conducted in Rajiv Gandhi Institute of Medical sciences, for 8 months Aug-2014 to March-2015with a sample size of 195 outpatients diagnosed with (HIV/AIDS) human immunodeficiency virus/acquired immune deficiency syndrome and on ART. Study subjects were aged between 18-60years the mean age group of males was 34.5 ± 2.12 years and females was 33.5 ± 2.12 years. Patients were followed up for 5 months.  RESULTS: The overall (QOL) Quality of life was score calculated with WHO-HIVBREF questionnaire scored from 0-100 and was found to be 75.15. The proportion of respondents with high was seen in the environmental domain (78.6%), followed by physical domain (76.22%), and social domains (75.7%). Lowest was observed in the psychological domain (74.59%). Total mean adherence scores by using Morisky-8-item medication adherence questionnaire were scored as a High-77.22%, Medium-22.66%, Low-0.12%. In males and females total mean scores were 62.36±36.83, 50.09±41.06 respectively-value for adherence was 0.034 which was significant. Pearson’s correlation coefficient value r = 0.98 which shows the linear relationship between and adherence. CONCLUSIONS: Males with income more than 5000, no formal education, married, coolis, living with spouse and on ART had high scores of adherence correlates to higher than to females with no formal education, married and income more than 3000 widowed, illiterates, unemployed and adherence were found to be related to education, income, occupation, ART status, duration of taking ART.