OBJECTIVES: Knowledge about pharmacovigilance among community pharmacists (CPs) is essential for better pharmaceutical care planning of the patients. This project was designed to assess community pharmacists’ knowledge, perceptions and practices towards pharmacovigilance in Punjab, Pakistan.  METHODS: A cross-sectional, questionnaire-based study was performed among registered CPs in Pakistan. A pre-tested and pre-validated research tool was used to collect data. The research tool was divided into three sections. Descriptive and inferential statistics were applied at a significant value of p≤ 0.05. Data were statistically analyzed using SPSS version 22.  RESULTS: A total of 131 CPs participated in the study (112% males with 19% females) and the response rate was 38%. Around 85% felt that only registered medical practitioners are responsible for ADRs and their reporting. Knowledge score about overall pharmacovigilance concept was relatively low among old graduates. Around 72% agreed they were not very well familiar with the pharmacovigilance concept, and only 11% knew that pharmacists are the key players in pharmacovigilance. Majority of them (78.0%) agreed that knowledge and awareness of pharmacovigilance is crucial for CPs in order to provide better pharmaceutical care to the patients. Foremost reason for non-awareness of pharmacovigilance concept was the misconception that it is the duty of medical doctors and hospital pharmacists not the CPs.  CONCLUSIONS: Based on the results of the study, specific and targeted educational interventions with some hands-on activities are crucial regarding pharmacovigilance advancements in Pakistan. This study indicated that CPs were not much aware about the importance and benefits of pharmacovigilance. The majority of community pharmacists in Punjab, Pakistan had poor knowledge and negative perception towards pharmacovigilance concept.