OBJECTIVES: Cardiac conditions are one of the most frequent chronic conditions seen in emergency rooms (ER). Clinical trials have shown that use of anti-hypertensive and antilipemic medications lead to reduction in cardiovascular events, which may prevent emergency care and reduce ER expenditures. This study examined the association between antihypertensive and antilipemic medication use and healthcare expenditures among adults with hypertension and hyperlipidemia. METHODS: A cross-sectional study was conducted using 2011 and 2013 data from Medical Expenditure Panel Survey (MEPS). Adults aged ≥21 years, who were alive, and had both hypertension and hyperlipidemia were included. Medication prescription was categorized into anti-hypertensives only, antilipemics only, both, and none. Generalized linear models (GLM) with gamma distribution and log link was fitted to examine the adjusted association between medication prescription and healthcare expenditures. These models accounted for the complex survey design of the MEPS. RESULTS: Of the