OBJECTIVES: The prognosis of lower extremity amputations is poor especially in patients with diabetes mellitus. However, there is limited data in the literature on Asian populations even though there is high prevalence of diabetes mellitus in Asian populations. Thus. we sought to examine 30-day and 1-year mortality rates of diabetes patients who underwent lower extremity amputations in Singapore METHODS: We performed a retrospective study of all lower extremity amputations performed at 3 hospitals in the years 2008 to 2013 in patients with diabetes mellitus (n=2,526) using the National Healthcare Group Diabetes Registry. All patients were followed up for at least 1 year and the outcomes of interest were death from all causes. The mortality data was obtained from the national death registry.   RESULTS: There were a total of 3,792 lower extremity amputations performed from 1 January 2008 to 31 December 2013. The mean age at amputation was 63.6 years and the mean age at death was 68.9 years. 197 patients (7.8%) died within 30 days and 577 patients (22.8%) died within 1 year. Those who died were older (68.9 years) compared to those who survivied. (62.0 years) The 30-day mortality rate was 6.3% in 2008 and it decreased steadily to 3.8% in 2013. However, the 1-year mortality rate remained constant from 19.8% in 2008 to 20.1% in 2013.   CONCLUSIONS: The 1-year mortality rates of diabetes patients who underwent lower extremity amputations remained high even though 30-days mortality rates have seen a gradual decline. Further research is needed to address this high mortality rate and further interventions is are needed to prevent lower extremity amputations in patients with diabetes mellitus.