OBJECTIVES: To examine the relationships between health-related quality of life and use of Internet for health related activities among patients with asthma. METHODS: The 2009 National Health Interview Survey and 2010 Medical Expenditure Panel Survey were used to select the study sample; 523 adult patients with asthma (n= 6,075,087 weighted). Health-related quality of life was the outcome of interest. The Andersen Model of Health Care Utilization was used to guide the selection of independent variables. Predisposing factors, enabling factors, need factors, smoking status, and health-related Internet activities comprised the independent variables. Five health-related Internet activities included 1) seeking health information on the Internet, 2) use online chat group to learn about health, 3) refill a prescription on the Internet, 4) schedule an appointment with a health care provider using the Internet, and 5) communicate with a health care provider over email. Linear regression analyses, incorporating the sampling weights, were employed. All analyses were conducted using STATA (version 13.1). RESULTS: Fifty percent of asthma patients reported performing at least one health-related Internet activity. The most reported activity was seeking health information on the Internet (49%). Mean physical component summary (PCS-12) and mental component summary (MCS-12) in asthma patients were 49.52 (SD=0.62) and 50.5 (SD=0.52). After controlling for independent variables, only scheduling an appointment with a health care provider using the Internet was significantly related to the physical component summary score (β = 4.94, 95% CI: 0.95 to 8.94). CONCLUSIONS: Study results suggest that the Internet plays a role in self-care and health-related quality of life among asthma patients. However, findings also indicate that asthma patients haven’t fully implemented using the Internet to accomplish all self-care tasks. Future research should examine the relationships between health-related Internet activities, health services utilization and outcomes.