OBJECTIVES: Despite the availability of effective prophylactic and therapeutic options, VTE continues to be under diagnosed and undertreated. The incidence of DVT in India, however, is comparable to that in the Western countries. This study aimed to assess the adherence of treatment guidelines in the prophylaxis of DVT and evaluated the risk factors associated with DVT. METHODS: The prospective study was carried out at an Indian tertiary healthcare setting where the patients were enrolled in the study as per the defined inclusion and exclusion criteria. The results are based on findings from a total of 230 patients. The patients were classified into four different categories based on the risk of DVT- low, moderate, high and highest.  RESULTS: The results are based on data obtained from 158 female and 72 male patients. The average age of the patients was found to be 62.1±0.9 yrs. The average age of female patients was found to be statistically significantly higher than the average age of male patients. Of 230 patients, 207 patients received Enoxaparin/ Rivaroxaban/ Diateparin for prophylaxis and 5 patients through DVT pump and limb physiotherapy. It was found that 18 patients did not receive any type of DVT prophylaxis; and, out of 18 patients, 10 were managed for DVT prophylaxis with active toe movements. The adherence to the pharmacological prophylaxis was found to be 92.2%. CONCLUSIONS: The results of this study have shown that the adherence to ACCP guidelines in DVT prophylaxis in this study population was high (92.2%). Further, an association between surgery (major surgery, orthopaedical surgery), age and DVT risk appears to be existent.