OBJECTIVES: Clinical trials for COPD are increasingly using electronic methods to collect patient-reported outcomes (ePRO). As use of this technology increases, it is important to consider patient preference in questionnaire design. This study examined patient preference for receiving real-time feedback while completing ePRO assessments. METHODS: A total of 103 patients with COPD were surveyed. Patients were asked to assume that they were using a handheld or tablet device to complete questionnaires as part of a clinical trial; they were then presented with example screens and asked about types of feedback they might receive on the device. RESULTS: Patients ranged in age from 32 to 86 years and were 55% female. 50% reported previous participation in a clinical trial. 59% reported that they would like to see a “thank you” screen at the end of each questionnaire. 81% thought it would be helpful or necessary to regularly receive a graph summarizing their responses. 81% preferred to see their progress as they completed a questionnaire; of these, 41% preferred a progress bar and “Question X of X” message and 47% preferred just the progress bar. 69% said they would like the first screen to summarize the questionnaire’s length and estimated completion time. Regarding feedback about daily diary compliance, 76% reported that a summary screen showing their percent compliance would motivate them to complete their diary each day. CONCLUSIONS: Patients with COPD prefer to receive real-time feedback while completing ePRO assessments, and are motivated by compliance information. Specifically, they prefer summaries of their data, the ability to track their progress through a questionnaire, and “thank you” messages for completing frequent questionnaires. Patients would be motivated to complete a daily dairy by seeing their overall percent compliance to date. Investigators should consider including these types of elements when designing ePRO assessments for clinical trials.