MEASUREMENT OF HEALTH STATE UTILITIES FOR RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA BY USING TIME TRADE-OFF AND VISUAL ANALOG SCALE METHOD
Author(s)
Kang HN, Choi I, Song H, Park S, Suh D
Chung-Ang University, Seoul, South Korea
OBJECTIVES: To elicit health utilities for refractory or relapsed peripheral T-cell lymphoma (PTCL) using visual analog scaling (VAS) and time trade-off (TTO) methods, to examine the impact of age on TTO values, and to estimate power curves to convert VAS scores to TTO values. METHODS: Health state vignettes for four health states (complete remission, partial response, stable disease and progressive disease) and four treatment-related adverse events (mucositis, thrombocytopenia, anemia, neutropenia) were developed. Utility elicitation from 125 Koreans from the general public living in Seoul was conducted using VAS and TTO methods. Linear mixed regression and generalized linear mixed models were used to assess the impact of age on TTO values. Nonlinear regression was used to estimate power curves to convert VAS scores to TTO values. RESULTS: Complete remission was the most preferred health state (mean TTO value: 0.885), followed by partial response, 0.784; stable disease, 0.746; and progressive disease, 0.567. Treatment related adverse events were related to significant negative impacts. The smallest disutility was associated with mucositis (mean TTO disutility: -0.075). The largest disutility was related to neutropenia (mean TTO disutility: -0.107). Age was not a significant determinant of utility values. Health state (p-value < 0.001) and cancer experience (p-value = 0.025) had a significant impact on preferences. Two power functions ( , were derived, where u = aggregated TTO values and v = aggregated VAS score. CONCLUSIONS: This study demonstrated that utility values and power curves for PTCL can be used in economic evaluations and decision making.
Conference/Value in Health Info
2015-05, ISPOR 2015, Philadelphia, PA, USA
Value in Health, Vol. 18, No. 3 (May 2015)
Code
PCN108
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities
Disease
Oncology