OBJECTIVES: The Short-Form 36 Health Survey version 2.0 (SF-36v2®) is a validated patient-reported outcome instrument.  A validated single-item format version exists for deployment on computer screens/tablet-sized devices, and an electronic handheld version was developed in 2012.  The objectives of this study were to evaluate measurement equivalence between the paper and electronic versions of the SF-36v2 administered using a handheld device or a smartphone app, and to determine patient preference for mode of administration. METHODS: This was a randomized crossover study in which 101 subjects with type II diabetes completed the SF-36v2 on two modalities: paper and either the electronic handheld (PHT LogPad® LW) or the smartphone App (PHT LogPad App).  Subjects completed the assessment in a single session with distraction activities between completion of the first and second modality and an exit survey which assessed patient preference for mode of administration.  RESULTS: Study data will be analyzed to test score level equivalence and to calculate the intraclass correlation coefficient (ICC) and other measures of measurement equivalence.  Equivalence analysis is in progress, and findings will be ready to present for this meeting.  82% of subjects found the electronic method easy to use and 80% found it easy to navigate.  Of those subjects who expressed a preference, 57% found it more physically comfortable and 69% found it faster to complete than paper.  65% would prefer the electronic method over paper when responding to questions in a clinical trial. CONCLUSIONS: This study will evaluate the measurement equivalence between standard paper versions of the SF-36v2 and electronic handheld versions as deployed on an electronic handheld device or a smartphone App.  Patients with diabetes generally prefer to complete the SF-36v2 electronically rather than on paper.