OBJECTIVES: The objective was to study the economic and humanistic outcomes among acute coronary syndrome patients receiving percutaneous coronary intervention (PCI) in a tertiary care setup in South India. METHODS: Total 240 acute coronary syndrome patients visiting to tertiary care multispecialty hospital in south India were included in to the study from 2011 to 2013. Prior ethical approval was taken and patients were included after signing the consent form. All the patients included were receiving PCI first time. Socio-demographic, clinical diagnostic and risk factor data was collected using a pilot tested data collection sheet. EQ5D was used to collect the humanistic data on discharge, 1 month, 3 month, 6 month follow up. The cost incurred in the intervention and other direct costs were taken from the bill paid by the patient at discharge. SPSS 15.0 was used to analyse the collected data and demographic results were represented with descriptive statistics and Mann-Whitney test was carried to compare the costs among both the groups. Repeated measures ANOVA was done to check the difference in VAS score in baseline and follow-up cases. RESULTS: