OBJECTIVES: To evaluate the Health related quality of life among patients using complementary Alternative medicine (homeopathy) in Quetta, Pakistan METHODS: A cross sectional, descriptive study was undertaken among the patients visiting three major homeopathic clinics in Quetta City, Pakistan. Health related quality of life was assessed using European Quality of Life scale (EQ-5D). Descriptive analysis was used to elaborate patients’ demographic characteristics while inferential statistics were applied to report the association among study variables.  RESULTS: Out of 500 questionnaires distributed 486 were received with a response rate of 97.2%. Gender distribution was 264 (54.4%) males. Mean age of the study participants was 34.05 ± 13.0 years with 334 (68.7%) married and 431 (88.7%) having urban residency. The mean EQ-5D descriptive score and EQ-VAS score were 0.59 ± 0.22 and 60.19 ±16.9 respectively. CONCLUSIONS: The health related quality of life in patients using Homeopathy is slightly low then Health related quality of life of general population of Quetta. This study provides baseline assessment for the health status of patients using homeopathy and the results could be applied in clinical practice.