OBJECTIVES: To evaluate the clinical effectiveness of Shuddha Guggulu (Commiphora mukul) in Hypothyroidism patients. METHODS: A randomized single blind clinical study with pretest and posttest design was adopted, where the patients were given treatment with specific duration with follow up. In total 379 patients were selected from the OPD of Muniyal Institute of Ayurvedic Medical Sciences Manipal enrolled for the present study out of which 32 were dropped out from the study. Thyroid function test, Routine hematological, bio-chemical and urine analysis were recorded. The main Signs and Symptoms weight and height ratio (BMI – Body Mass Index), Joint pain, Muscle cramps and Tiredness were taken for assessment as symptoms grade parameters. Elevation of value of T3 and T4 to normal range, decline the TSH value to normal range and Blood Cholesterol also taken for the assessment as Laboratory parameters. Data obtained from the above mentioned study was statistically analyzed by using the Z test. RESULTS: Shuddha Guggulu provided 55.55%. relief in Joint pain and 23.68%, relief in Tiredness which were statistically highly significant result p<0.001, where as in Body mass index, Muscle cramps and Anorexia provided 2.2%, 45.45% and 38.71% relief respectively which were also statistically highly significant result p<0.005. Shuddha Guggulu provided 23.73% relief in Triiodothyronine (T3), 26.72% relief in Thyroxin (T4), 45.86% relief in Thyroid Stimulating Hormone (TSH) and 10.47% relief in Blood Cholesterol which were statistically showing highly significant result P <0.001. CONCLUSIONS: Shuddha guggulu appears to be beneficial in those who have metabolic syndrome which includes high blood Cholesterol, obesity, and an overall inflammatory pattern. Whether it stimulates thyroid function in every condition is still being evaluated.