OBJECTIVES: Integrated delivery models in the outpatient setting such as Medical Homes (MHs) require effective interprofessional communication and collaborative practice. Our objective was to evaluate the attitudes towards collaboration of nurses, general practitioners (GPs), and specialists practicing in newly established MHs in the Parma Local Health Authority, Italy. METHODS: The 15 item Jefferson Scale of Attitudes Toward Physician-Nurse Collaboration was administered electronically to 172 physicians (66 GPs, 106 specialists) and 113 nurses practicing in 12 MHs, caring for an overall population of about 90,000 patients. Possible scores of the scale range from 15 to 60 with higher scores representing a more positive attitude toward collaboration. The scale also contains three factors that measure: a) shared education and teamwork; b) caring versus curing; c) physician authority. Categorical variables were compared with Chi square or Fisher’s exact tests; continuous variables were compared using t-tests or ANOVA, as appropriate. RESULTS: A total of 191 surveys (45 GPs, 59 specialists, 87 nurses) were completed for an overall 67% response rate. The mean total score among nurses (51.5, Standard Deviation 3.7) reflected a significantly (p<0.01) more positive attitude towards collaboration compared with GPs (47.8, SD 4.6) and specialists (45.3, SD 7.7). This hierarchy was observed consistently for all three factors with the exception of physician authority, upon which general practitioners’ and specialists’ each expressed strong perceptions of nurses as assistants rather than collaborators. CONCLUSIONS: Nurses consistently conveyed positive responses, indicative of a willingness to collaborate and to take on additional responsibility within the MH environment in Parma Local Health Authority.  GPs and specialists responded in agreement with most items, although lower scores suggested a relative temperate attitude towards physician-nurse collaboration. Further research into interprofessional relationships within MHs is needed to inform policy and develop educational initiatives to build a necessary culture of team-based care.