ASSESSMENT OF DRUG UTILIZATION PATTERN AND CLINICAL OUTCOME IN PREGNANCY INDUCED HYPERTENSION IN TERITARY CARE HOSPITAL
Author(s)
Bandari mM
kakatiya university, warangal, India
OBJECTIVES: The objective of this thesis is to study and evaluate the Dug utilization pattern and clinical outcome in pregnancy induced hypertension in tertiary care hospitals. METHODS: This Retrospective observational study was carried out in department of obstetrics and gynaecology, CKM and Vishwas hospital, S.V.R. Hospital, warangal.Data were collected as per inclusion and exclusion criteria and analyzed for drug utilization pattern of antihypertensive drugs with their teratogenic risk category as well as for WHO drug use indicators at initiation and during entire study period. Neonatal morbidity and mortality outcome was also assessed. RESULTS: Out of the 165 total prescriptions studied majority were in age group 21-25years,illiterates and low income group.The most commonly prescribed antihypertensive Monotherapy was Methyldopa (35.1%) followed by Nifedipine (18.78%). Labetolol and Nifedipine combination was most commonly used multi drug regimen(9.69%). Majority drugs prescribed were from category B and C. Average number of drugs per prescription are five.Single drug therapy was prescribed in 72.21 % patients.50% of the drugs are from WHO essential drug list of 18th edition. The most common neonatal outcome was low birth weight (84.88%), followed by foetal distress (9.30%), neonatal deaths(3.48%) and IUGR(2.32%).A significant correlation was found between Diastolic blood pressure of mother and neonatal morbidity and mortality rate. CONCLUSIONS: Methyldopa was the commonly prescribed antihypertensive in monotherapy as well as combination for PIH. This necessitates the development, implementation, and evaluation of policies on the use of antihypertensive drugs. The incidence of high neonatal morbidity and mortality is associated with maternal hypertension. Early diagnosis and treatment through regular antenatal check-up is a key factor to prevent PIH and its complications. Interventions to improve maternal health through information, education and counselling of women of child bearing age should be implemented.
Conference/Value in Health Info
2015-05, ISPOR 2015, Philadelphia, PA, USA
Value in Health, Vol. 18, No. 3 (May 2015)
Code
PCV44
Topic
Clinical Outcomes, Epidemiology & Public Health
Topic Subcategory
Relating Intermediate to Long-term Outcomes, Safety & Pharmacoepidemiology
Disease
Cardiovascular Disorders