OBJECTIVES: Analysis of the consumption of antibiotics plays a very important role in hospital care, since it allows the identification of areas where measures to improve the suitability for use and rationalization of resources should be adopted, stimulating improve the quality and development of surveillance strategies antibiotic resistance. The consumption of antibiotics in Slovak hospitals is still high compared with the other European countries. The aim of the study was to analyze the utilisation of antibiotics in the hospital sector in Slovakia. METHODS: Drug’s expenditure derived from the State Institute of Drug Control. Antibiotic drug consumption was expressed as number of packages and as DDDs per 1000 inhabitants per day (DID). Data were analyzed according to ATC classification. RESULTS: During the period 2011 – 2014 was increased consumption of antibiotics - expressed as number of packages - in the ATC group J01D, in the community sector (primary care sector). By contrast, in the hospital pharmacies, the consumption gradually decreases. The Macrolides (J01F), one of the most prescribed antibiotics in community sector reach 30% of the total volume consumed antibiotics in the community, in hospital sector but only 5%. While consumption of penicillins in hospital sector is increasing slightly (5% during the period), in the group of other beta-lactam antibiotics, decrease (10 % during the period). CONCLUSIONS: According of the antibiotics costs demonstrated the development of consumption during the analyzed period decreasing trend. The decreasing consumption of antibiotics in community sector leads to increase of consumptions in hospital sector. The other analysis of consumption at the hospital level should help health care providers to improve antibiotic use.