TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS- REAL WORLD POPULATION-BASED EVIDENCE FROM FRANCE.
Author(s)
Mercier G, Marouen S, Bourel G, Georgescu V
CHU Montpellier, Montpellier, France
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease posing a high burden on patients and healthcare systems. Appropriate use of conventional and biological disease-modifying antirheumatic drugs (cDMARDs and bDMARDs) is key to optimal therapeutic success. However little is known about the treatment patterns in real world settings. Our aim was to assess the real world, population-based treatments of patients with RA in France. METHODS: A retrospective, national, population-based study was conducted in France. Data were retrieved from EGB database (a 1/97 sample from the national claims database covering all patients in France). All patients with either an acute care hospital admission mentioning RA (ICD-10 codes M05-06) as primary or secondary diagnosis or a full insurance coverage (ALD) for RA in 2015 were included. All deliveries of cDMARDs (methotrexate) or bDMARDs (anti-TNF or other mechanisms of action drugs) were retrieved from the database, from both hospital and community-based pharmacies. RESULTS: We included 2,490 patients aged 65 (SD: 15) on average of whom 1,793 (72%) were female. In 2015, 1,139 patients (46%) had at least one methotrexate delivery; 320 (13%) had at least one bDMARD delivery of whom 257 were only on anti-TNF drugs, 53 were only on other mechanisms of action bDMARDs, and 10 received both anti-TNF and other mechanisms of action bDMARDs during the year. CONCLUSIONS: This study provides new and valuable insight into the real-world, population-based treatment patterns of patients with RA in France. Further analyses need to be conducted to understand the dynamics of treatment adaptation, switch and associations.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PMS84
Topic
Health Service Delivery & Process of Care
Topic Subcategory
Prescribing Behavior
Disease
Musculoskeletal Disorders