THE HEALTH-RELATED QUALITY OF LIFE (HRQOL) ASSOCIATED WITH OSTOMY APPLIANCES AND FEATURES
Author(s)
Boisen EB1, Bøgelund M2
1Aalborg University, Aalborg, Denmark, 2Incentive, Holte, Denmark
Presentation Documents
OBJECTIVES: Differences between ostomy appliances have until now only been documented using condition-specific tools. However, these results are not applicable in standard economic evaluations which require a common metric for measuring outcomes, such as QALY-values. This study, therefore, aimed to investigate the incremental health-related quality of life (HRQoL) associated with different ostomy appliances and features using a time trade-off (TTO) internet experiment. METHODS: The HRQoL associated with the ostomy appliances and features were investigated in a TTO internet experiment. Respondents traded off life expectancy for improved quality of life following the standard bisection methodology. The health states were described using evidence relating to function, appearance, waterproofness, comfort and fit, confidence, skin problems and ballooning. Two populations were included in the study: 1013 respondents from a British general population (BGP) and 237 respondents from a Swedish ostomate population (SOP) consisting of ostomates with either a colostomy or an ileostomy. Confidence intervals were determined using bootstrapping with resampling, and 5% outliers were excluded from the main analysis. A sensitivity analysis was conducted to investigate the impact of outliers on the incremental HRQoL. RESULTS: All health states showed statistically significant improvements in HRQoL, at the 0.05 significance level. The health states for ostomy appliances showed an incremental utility ranging from of 0.017-0.036 in the BGP and 0.015-0.038 in the SOP. Only minor differences were observed in the incremental utility values between the two populations. The sensitivity analysis showed that the BGP outliers had little impact on the incremental utility values, while the SOP outliers added to the incremental utility values. CONCLUSIONS: The study confirmed that the TTO method can be used to measure HRQoL related to ostomy appliances and found statistically significant differences in HRQoL associated with improvements in ostomy appliance attributes and features.
Conference/Value in Health Info
2017-11, ISPOR Europe 2017, Glasgow, Scotland
Value in Health, Vol. 20, No. 9 (October 2017)
Code
PMD106
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities, Patient-reported Outcomes & Quality of Life Outcomes
Disease
Gastrointestinal Disorders, Oncology